Innovative Research of America(IRA)—藥物定量定時(shí)緩釋系統(tǒng)

Innovative Research of America(IRA) 是一家致力研發(fā)于藥物定量定時(shí)緩釋系統(tǒng)的專(zhuān)業(yè)化公司，又稱(chēng)Matrix-Driven Delivery (MDD) 給藥系統(tǒng)。該給藥系統(tǒng)由一個(gè)可生物吸收的基質(zhì)組成，含有定量可控的活性給藥成分，可以以設(shè)定的劑量在一定時(shí)間范圍內(nèi)進(jìn)行給藥。

給藥天數(shù)及劑量的選擇：依據(jù)研究人員實(shí)驗(yàn)需要確定，如某實(shí)驗(yàn)需要在3周內(nèi)給大鼠皮下給某種藥x mg，首先在本公司產(chǎn)品目錄中選取該種藥物，然后選取21天緩釋時(shí)間，劑量選擇可以如下方式進(jìn)行：21天共給藥量或每天給藥量，計(jì)算出總的藥物劑量。本公司常規(guī)的給藥時(shí)間有21，,60，90天，即可選擇21天的給藥時(shí)間（如常規(guī)給藥時(shí)間不滿(mǎn)足實(shí)驗(yàn)設(shè)計(jì)，可公司進(jìn)行產(chǎn)品定制）。同樣，給如本公司提供的常規(guī)給藥劑量不滿(mǎn)足實(shí)驗(yàn)設(shè)計(jì)，也可公司進(jìn)行產(chǎn)品定制。本公司可根據(jù)客戶(hù)需要在給藥系統(tǒng)中加入可在規(guī)定期間釋放一定劑量的活性藥物。

給藥方法：皮下（一般選取背部或頸部皮膚松弛部位）植入本給藥系統(tǒng)。手工植入方法為選取植入部位，切開(kāi)一個(gè)藥丸直徑相當(dāng)?shù)那锌?，以無(wú)菌鑷子自切口探入，深入皮下至2cm處，用鑷子將藥丸送入離切口2cm處，縫合切口即可。切忌：（1）切口及鑷子探入時(shí)傷及肌肉層，可引起炎癥，影響藥物釋放及實(shí)驗(yàn)；（2）鑷子送入藥丸時(shí)切勿破壞藥丸，否則影響藥丸緩釋效應(yīng)，影響實(shí)驗(yàn)結(jié)果。

使用套針給藥（另售）：將藥丸放入給藥套針，選取給藥點(diǎn)，扎入針頭，在不傷及肌肉的情況下將針深入扎入處2cm，將藥丸推入皮下，抽出套針即可，無(wú)需縫合。

相關(guān)參考文獻(xiàn)：

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3. DAMASSA, GUSTAFSON, KWIECINSKI, PRATT. BIOLOGY OF REPRODUCTION, 33 (5) : pp.1138-1146, 1985. Product. D-THYROXINE - Dosage 0.5MG - Release Time 21-DAY - Pellet Type: Stock.

4. WASHBURN, KRANTZ, AVERY, REEDLAND.FASEB ABSTRACT FORM 535-5, 1990. 17ß-ESTRADIOL - Release Time 21-DAY - Pellet Type: Stock.

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12 .BIANCO, STRIZZI, EBERT, CHANG, REHMAN, NORMANNO, GUEDEZ, SALLOUM, GINSBURG, SUN, KHAN, HIROTA, WALLACE-JONES, WECHSELBERGER, VONDERHAAR, TOSATO, STETLER-STEVENSON, SANICOLA, SALOMON. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 97 (2) : pp.132-141, 2005. Product .17ß-ESTRADIOL - Dosage 0.72 MG - Release Time 60-day - Pellet Type: Stock.

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